Media type: E-Article Title: Corrosion of machined titanium dental implants under inflammatory conditions Contributor: Messer, Regina L. W.; Tackas, Gyula; Mickalonis, John; Brown, Yolanda; Lewis, Jill B.; Wataha, John C. imprint: Wiley, 2009 Published in: Journal of Biomedical Materials Research Part B: Applied Biomaterials Language: English DOI: 10.1002/jbm.b.31162 ISSN: 1552-4973; 1552-4981 Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>The effects of hyperglycemia, altered cell function, or inflammatory mediators on implant corrosion are not well studied; yet, these effects are critical to implant biocompatibility and osseointegration. Because implant placement is burgeoning, patients with medically compromising systemic conditions such as diabetes are increasingly receiving implants, and the role of other inflammatory diseases on implant corrosion also needs investigation. In the current study, the corrosion properties of commercially available, machined titanium implants were studied in blood, cultures of monocytic cells, and solutions containing elevated dextrose concentrations. Implant corrosion was estimated by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy (EIS) for 26 h. In selected samples, THP1 monocytic cells were activated for 2 h with Lipopolysaccharide prior to implant exposure, and IL‐1β secretion was measured to assess the affect of the implants on monocyte activation. Implants under conditions of inflammatory stress exhibited more negative <jats:italic>E</jats:italic><jats:sub>corr</jats:sub> values, suggesting an increased potential for corrosion. Linear polarization measurements detected increased corrosion rates in the presence of elevated dextrose conditions over PBS conditions. EIS measurements suggested that implants underwent surface passivation reactions that may have limited corrosion over the short term of this test. This result was supported by cyclic polarization tests. IL‐1β secretion was not altered under conditions of corrosion or implant exposure. The results suggest that inflammatory stress and hyperglycemia may increase the corrosion of dental endosseous titanium‐based implants, but that longer, more aggressive electrochemical conditions may be necessary to fully assess these effects. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009</jats:p>