Description:
<jats:title>Abstract</jats:title>
<jats:p>Genome-wide association studies (GWASs) have identified three chromosomal regions at 5p15, 6p21, and 15q25 as being associated with lung cancer risk in European populations. This study was performed to confirm these associations in Korean patients with lung cancer. The genotypes of rs2736100, rs402710, rs401681, and rs31489 at 5p15, rs9295740 at 6p22, and rs2036534 and rs6495309 at 15q25 were determined in 1094 lung cancer patients and 1100 healthy controls frequency-matched for age and gender. The single nucleotide polymorphisms (SNPs) at 5p15 and 15q25 were significantly associated with lung cancer risk. The magnitude of effect was similar to that reported in previous studies and the association was in the same direction. The effect of SNPs at 5p15 region on the risk of lung cancer was significant only in adenocarcinoma. The two SNPs at 15q25 region were significantly associated with lung cancer risk in ever-smokers and squamous cell carcinoma. However, there was no association between the SNP at 6p22 and lung cancer risk. We confirmed the association between SNPs at the 5p15 and 15q25 regions and the risk of lung cancer in a Korean population.</jats:p>
<jats:p>Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2110. doi:1538-7445.AM2012-2110</jats:p>