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Lütticken, Claudia; Wegenka, Ursula M.; Yuan, Juping; Buschmann, Jan; Schindler, Chris; Ziemiecki, Andrew; Harpur, Ailsa G.; Wilks, Andrew F.; Yasukawa, Kiyoshi; Taga, Tetsuya; Kishimoto, Tadamitsu; Barbieri, Giovanna; Pellegrini, Sandra; Sendtner, Michael; Heinrich, Peter C.; Horn, Friedemann

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

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  • Media type: E-Article
  • Title: Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130
  • Contributor: Lütticken, Claudia; Wegenka, Ursula M.; Yuan, Juping; Buschmann, Jan; Schindler, Chris; Ziemiecki, Andrew; Harpur, Ailsa G.; Wilks, Andrew F.; Yasukawa, Kiyoshi; Taga, Tetsuya; Kishimoto, Tadamitsu; Barbieri, Giovanna; Pellegrini, Sandra; Sendtner, Michael; Heinrich, Peter C.; Horn, Friedemann
  • imprint: American Society for the Advancement of Science, 1994
  • Published in: Science
  • Language: English
  • ISSN: 0036-8075; 1095-9203
  • Keywords: Reports
  • Origination:
  • Footnote:
  • Description: <p> Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3α (ISGF-3α). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3α p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp 130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp 130. </p>