• Medientyp: E-Artikel
  • Titel: Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer : results of the FOGT-4 trial
  • Beteiligte: Schulz, Anna [VerfasserIn]; Knebel Doeberitz, Magnus von [VerfasserIn]; Kloor, Matthias [VerfasserIn]
  • Erschienen: 21 February 2012
  • Erschienen in: British journal of cancer ; 106(2012), 6, Seite 1239-1245
  • Sprache: Englisch
  • DOI: 10.1038/bjc.2012.53
  • ISSN: 1532-1827
  • Identifikator:
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Background: High-level microsatellite instability (MSI-H) has been reported as a prognostic marker in colon cancer. We here analysed the prognostic significance of MSI and mutations of the Beta2-Microglobulin (B2M) gene, which occur in about 30% of MSI-H colon cancer, in the cohort of the prospective FOGT-4 (Forschungsruppe Onkologie Gastrointestinale Tumoren, FOGT) trial. Methods: Microsatellite instability status was determined using standard protocols (NCI/ICG-HNPCC panel and CAT25) in 223 colon cancer lesions. Beta2-Microglobulin mutation status was evaluated by exon-wise sequencing in all MSI-H lesions. Results: Patients with MSI-H (n=34) colon cancer presented with a significantly lower risk of relapse after 12 months of follow-up compared with MSS (n=189) colon cancer patients (5 year time to relapse: MSI-H 0.82 vs MSS 0.66, P=0.03). No significant difference in overall survival was detected. Beta2-Microglobulin mutations were identified in 10 (29.4%) out of 34 MSI-H colon cancers and were associated with a complete absence of disease relapse or tumour-related death events (P=0.09). Conclusion: The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer. Moreover, B2M mutations may contribute to the favourable outcome of MSI-H colon cancer patients and should therefore be evaluated as a potential prognostic marker in future clinical trials.
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