Beschreibung:
RNA helicases of the DEAH-box family fulfill essential functions in various aspects of RNA metabolism by reorganizing structured RNAs and RNPs through ATP-dependent motility in 3’ to 5’ direction along single-strands. Prp43 acts on several targets in pre-mRNA splicing and ribosome biogenesis. In the specific cellular context Prp43 is activated by G-patch factors which enhance its intrinsically low ATPase and RNA unwinding activity. To initiate unwinding, a single stranded RNA segment preceding the helicase target needs to be accommodated in a binding channel formed between the helicase core...