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Kaye, Jane [VerfasserIn]; Hurles, Matthew [VerfasserIn]; Griffin, Heather [VerfasserIn]; Grewal, Jasjote [VerfasserIn]; Bobrow, Martin [VerfasserIn]; Timpson, Nic [VerfasserIn]; Smee, Carol [VerfasserIn]; Bolton, Patrick [VerfasserIn]; Durbin, Richard [VerfasserIn]; Dyke, Stephanie [VerfasserIn]; Fitzpatrick, David [VerfasserIn]; Kennedy, Karen [VerfasserIn]; Kent, Alastair [VerfasserIn]; Muddyman, Dawn [VerfasserIn]; Muntoni, Francesco [VerfasserIn]; Raymond, Lucy F. [VerfasserIn]; Semple, Robert [VerfasserIn]; Spector, Tim [VerfasserIn]

Managing clinically significant findings in research: The UK10K example - [published Version]

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  • Medientyp: Sonstige Veröffentlichung; E-Artikel
  • Titel: Managing clinically significant findings in research: The UK10K example
  • Beteiligte: Kaye, Jane [VerfasserIn]; Hurles, Matthew [VerfasserIn]; Griffin, Heather [VerfasserIn]; Grewal, Jasjote [VerfasserIn]; Bobrow, Martin [VerfasserIn]; Timpson, Nic [VerfasserIn]; Smee, Carol [VerfasserIn]; Bolton, Patrick [VerfasserIn]; Durbin, Richard [VerfasserIn]; Dyke, Stephanie [VerfasserIn]; Fitzpatrick, David [VerfasserIn]; Kennedy, Karen [VerfasserIn]; Kent, Alastair [VerfasserIn]; Muddyman, Dawn [VerfasserIn]; Muntoni, Francesco [VerfasserIn]; Raymond, Lucy F. [VerfasserIn]; Semple, Robert [VerfasserIn]; Spector, Tim [VerfasserIn]
  • Erschienen: London : Nature Publishing Group, 2014
  • Erschienen in: European Journal of Human Genetics 22 (2014), Nr. 9
  • Ausgabe: published Version
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/1073; https://doi.org/10.1038/ejhg.2013.290
  • ISSN: 1018-4813
  • Schlagwörter: sequencing ; lifespan ; consortia ; informed consent ; human ; clinically significant finding ; management pathway ; ethics ; feedback system ; gene sequence ; incidental findings ; research ; interpersonal communication ; article ; clinical genetics ; incidental finding ; clinical research ; genetic variability ; human genome ; genetic counseling
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Recent advances in sequencing technology allow data on the human genome to be generated more quickly and in greater detail than ever before. Such detail includes findings that may be of significance to the health of the research participant involved. Although research studies generally do not feed back information on clinically significant findings (CSFs) to participants, this stance is increasingly being questioned. There may be difficulties and risks in feeding clinically significant information back to research participants, however, the UK10K consortium sought to address these by creating a detailed management pathway. This was not intended to create any obligation upon the researchers to feed back any CSFs they discovered. Instead, it provides a mechanism to ensure that any such findings can be passed on to the participant where appropriate. This paper describes this mechanism and the specific criteria, which must be fulfilled in order for a finding and participant to qualify for feedback. This mechanism could be used by future research consortia, and may also assist in the development of sound principles for dealing with CSFs. © 2014 Macmillan Publishers Limited All rights reserved. ; Wellcome Trust/WT091310 ; Wellcome Trust/WT096599/2/11/Z
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)