Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of micro-RNA-21 through a highly conserved enhancer

Medientyp: E-Artikel

Titel: Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of micro-RNA-21 through a highly conserved enhancer

Beteiligte: Löffler, Dennis [VerfasserIn]; Brocke-Heidrich, Katja [VerfasserIn]; Pfeifer, Gabriele [VerfasserIn]; Stocsits, Claudia [VerfasserIn]; Hackermüller, Jörg [VerfasserIn]; Kretzschmar, Antje K. [VerfasserIn]; Burger, Renate [VerfasserIn]; Gramatzki, Martin [VerfasserIn]; Blumert, Conny [VerfasserIn]; Bauer, Kay [VerfasserIn]; Cvijic, Helena [VerfasserIn]; Ullmann, Kerstin [VerfasserIn]; Stadler, Peter F. [VerfasserIn]; Horn, Friedemann [VerfasserIn]

Erschienen: [2018]

Sprache: Englisch

ISSN: 0006-4971

Schlagwörter: Evolutionary biology ; RNA ; Biochemistry

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Beschreibung: Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3.

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