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Salameh, Ahmad; Lee, Alessandro K.; Cardó-Vila, Marina; Nunes, Diana N.; Efstathiou, Eleni; Staquicini, Fernanda I.; Dobroff, Andrey S.; Marchiò, Serena; Navone, Nora M.; Hosoya, Hitomi; Lauer, Richard C.; Wen, Sijin; Salmeron, Carolina C.; Hoang, Anh; Newsham, Irene; Lima, Leandro A.; Carraro, Dirce M.; Oliviero, Salvatore; Kolonin, Mikhail G.; Sidman, Richard L.; Do, Kim-Anh; Troncoso, Patricia; Logothetis, Christopher J.; Brentani, Ricardo R.; [...]

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3

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  • Medientyp: E-Artikel
  • Titel: PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3
  • Beteiligte: Salameh, Ahmad; Lee, Alessandro K.; Cardó-Vila, Marina; Nunes, Diana N.; Efstathiou, Eleni; Staquicini, Fernanda I.; Dobroff, Andrey S.; Marchiò, Serena; Navone, Nora M.; Hosoya, Hitomi; Lauer, Richard C.; Wen, Sijin; Salmeron, Carolina C.; Hoang, Anh; Newsham, Irene; Lima, Leandro A.; Carraro, Dirce M.; Oliviero, Salvatore; Kolonin, Mikhail G.; Sidman, Richard L.; Do, Kim-Anh; Troncoso, Patricia; Logothetis, Christopher J.; Brentani, Ricardo R.; [...]
  • Erschienen: Proceedings of the National Academy of Sciences, 2015
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1507882112
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p> Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the most often used test in prostate cancer but screening is controversial. Treatment options are limited for metastatic disease, hence the need for early diagnosis. Prostate cancer antigen 3 ( <jats:italic>PCA3</jats:italic> ), a long noncoding RNA, is the most specific biomarker identified and approved as a diagnostic test. However, its inherent biological function (if any) has remained elusive. We uncovered a negative transdominant oncogenic role for <jats:italic>PCA3</jats:italic> that down-regulates an unrecognized tumor suppressor gene, <jats:italic>PRUNE2</jats:italic> (a human homolog of the <jats:italic>Drosophila</jats:italic> prune gene) thereby promoting malignant cell growth. This work defines a unique biological function for <jats:italic>PCA3</jats:italic> in prostate cancer. </jats:p>
  • Zugangsstatus: Freier Zugang