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Gupta, Sarthak; Nakabo, Shuichiro; Blanco, Luz P.; O’Neil, Liam J.; Wigerblad, Gustaf; Goel, Rishi R.; Mistry, Pragnesh; Jiang, Kan; Carmona-Rivera, Carmelo; Chan, Diana W.; Wang, Xinghao; Pedersen, Hege L.; Gadkari, Manasi; Howe, Katherine N.; Naz, Faiza; Dell’Orso, Stefania; Hasni, Sarfaraz A.; Dempsey, Caeden; Buscetta, Ashley; Frischmeyer-Guerrerio, Pamela A.; Kruszka, Paul; Muenke, Maximilian; Franco, Luis M.; Sun, Hong-Wei;

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism

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  • Medientyp: E-Artikel
  • Titel: Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
  • Beteiligte: Gupta, Sarthak; Nakabo, Shuichiro; Blanco, Luz P.; O’Neil, Liam J.; Wigerblad, Gustaf; Goel, Rishi R.; Mistry, Pragnesh; Jiang, Kan; Carmona-Rivera, Carmelo; Chan, Diana W.; Wang, Xinghao; Pedersen, Hege L.; Gadkari, Manasi; Howe, Katherine N.; Naz, Faiza; Dell’Orso, Stefania; Hasni, Sarfaraz A.; Dempsey, Caeden; Buscetta, Ashley; Frischmeyer-Guerrerio, Pamela A.; Kruszka, Paul; Muenke, Maximilian; Franco, Luis M.; Sun, Hong-Wei;
  • Erschienen: Proceedings of the National Academy of Sciences, 2020
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.2003603117
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p>Despite clear differences in female and male immunity that may contribute to variations in response to infections and predisposition to cancer and autoimmunity, the exact mechanisms that drive this stark contrast remain insufficiently characterized. Neutrophils play essential roles in homeostasis and disease, but little is known about how sex differences modulate their phenotype and function. Using transcriptomic and functional approaches, we report that healthy young adult females have an activated/mature neutrophil profile characterized by enhanced type I IFN pathway activity, enhanced proinflammatory responses, and distinct bioenergetics. We further show that these differences are cell specific and likely driven by sex hormones. Modulation of these pathways in neutrophils may provide more individualized, sex-specific therapeutic options in a variety of disease states.</jats:p>
  • Zugangsstatus: Freier Zugang