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Bastard, Paul;
Gervais, Adrian;
Taniguchi, Maki;
Saare, Liisa;
Särekannu, Karita;
Le Voyer, Tom;
Philippot, Quentin;
Rosain, Jérémie;
Bizien, Lucy;
Asano, Takaki;
Garcia-Prat, Marina;
Parra-Martínez, Alba;
Migaud, Mélanie;
Tsumura, Miyuki;
Conti, Francesca;
Belot, Alexandre;
Rivière, Jacques G.;
Morio, Tomohiro;
Tanaka, Junko;
Javouhey, Etienne;
Haerynck, Filomeen;
Duvlis, Sotirija;
Ozcelik, Tayfun;
Keles, Sevgi;
[...]
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
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- Medientyp: E-Artikel
- Titel: Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
- Beteiligte: Bastard, Paul; Gervais, Adrian; Taniguchi, Maki; Saare, Liisa; Särekannu, Karita; Le Voyer, Tom; Philippot, Quentin; Rosain, Jérémie; Bizien, Lucy; Asano, Takaki; Garcia-Prat, Marina; Parra-Martínez, Alba; Migaud, Mélanie; Tsumura, Miyuki; Conti, Francesca; Belot, Alexandre; Rivière, Jacques G.; Morio, Tomohiro; Tanaka, Junko; Javouhey, Etienne; Haerynck, Filomeen; Duvlis, Sotirija; Ozcelik, Tayfun; Keles, Sevgi; [...]
- Erschienen: Rockefeller University Press, 2024
- Erschienen in: Journal of Experimental Medicine
- Sprache: Englisch
- DOI: 10.1084/jem.20231353
- ISSN: 0022-1007; 1540-9538
- Schlagwörter: Immunology ; Immunology and Allergy
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:p>We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.</jats:p>