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Shiau, Stephanie; Jacobson, Denise L; Huo, Yanling; Kacanek, Deborah; Yee, Lynn M; Williams, David B; Haddad, Lisa B; Serghides, Lena; Powis, Kathleen; Sperling, Rhoda S; Williams, Paige L; Jao, Jennifer; Chadwick, Ellen; Sanders, Margaret Ann; Malee, Kathleen; Paul, Mary; Eser-Jose, Ruth; McMullen-Jackson, Chivon; Harris, Lynnette; Purswani, Murli; Baig, Mahoobullah Mirza; Villegas, Alma; Alvarado, Marvin; Robinson, Lisa-Gaye; [...]

Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States

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  • Medientyp: E-Artikel
  • Titel: Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States
  • Beteiligte: Shiau, Stephanie; Jacobson, Denise L; Huo, Yanling; Kacanek, Deborah; Yee, Lynn M; Williams, David B; Haddad, Lisa B; Serghides, Lena; Powis, Kathleen; Sperling, Rhoda S; Williams, Paige L; Jao, Jennifer; Chadwick, Ellen; Sanders, Margaret Ann; Malee, Kathleen; Paul, Mary; Eser-Jose, Ruth; McMullen-Jackson, Chivon; Harris, Lynnette; Purswani, Murli; Baig, Mahoobullah Mirza; Villegas, Alma; Alvarado, Marvin; Robinson, Lisa-Gaye; [...]
  • Erschienen: Oxford University Press (OUP), 2023
  • Erschienen in: The Journal of Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/infdis/jiac501
  • ISSN: 1537-6613; 0022-1899
  • Schlagwörter: Infectious Diseases ; Immunology and Allergy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.</jats:p> </jats:sec>