Beschreibung:
<jats:sec><jats:label /><jats:p>We previously reported that total peripheral resistance is increased by AngII in rats consuming a high salt diet, and that this response is attenuated by denervation of the mesenteric vascular bed. Based on these observations, we hypothesize that mesenteric vascular resistance (MVR) is increased in AngII rats consuming a high salt diet. In this study, rats on either a high (2%) or low (0.1%) NaCl diet were chronically instrumented for continuous measurement of MAP and superior mesenteric artery blood flow (MBF). AngII was infused (150 ng/kg/min, sc) for 14 days preceded by 4 days of control. MVR was calculated as MAP/MBF. 0.1% NaCl rats showed minimal responses to AngII. MAP during the control period, and Days 1 and 14 of AngII were 100±2, 103±4 and 104±4 mm Hg respectively. In contrast, in 2% NaCl rats, MAP was 111±3 during control and 126±5 and 140±10, on Days 1 and 14 of AngII. MBF was fairly constant within the two groups. In 0.1% NaCl rats MBF was 12.5±0.9, 12±1, 12.5±0.4 mL/min during control and Days 1 and 14 of AngII. In 2% NaCl rats, MBF averaged 10±1, 8±1, 10±2 mL/min over the same time period. MVR remained stable in 0.1%NaCl rats during control and Days 1 and 14 of AngII (8.0±0.7, 8.6±0.9, 8.3 ±0.6 a.u. respectively). In contrast, MVR increased from a control level of 11±1, to 16±3 on Day 1, and 14±4 a.u. on Day 14 of AngII. We conclude that AngII increases MVR in rats consuming a high salt diet but not those on a low salt diet. HL064178.</jats:p></jats:sec>