Failure to replicate effect of kibra on human memory in two large cohorts of European origin

Medientyp: E-Artikel
Titel: Failure to replicate effect of kibra on human memory in two large cohorts of European origin
Beteiligte: Need, Anna C.; Attix, Deborah K.; McEvoy, Jill M.; Cirulli, Elizabeth T.; Linney, Kristen N.; Wagoner, Ana Patricia; Gumbs, Curtis E.; Giegling, Ina; Möller, Hans‐Jürgen; Francks, Clyde; Muglia, Pierandrea; Roses, Allen; Gibson, Greg; Weale, Mike E.; Rujescu, Dan; Goldstein, David B.
Erschienen: Wiley, 2008
Erschienen in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Sprache: Englisch
DOI: 10.1002/ajmg.b.30658
ISSN: 1552-4841; 1552-485X
Schlagwörter: Cellular and Molecular Neuroscience ; Psychiatry and Mental health ; Genetics (clinical)
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory. © 2008 Wiley‐Liss, Inc.</jats:p>

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