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Ophey, Anja; Wolfsgruber, Steffen; Roeske, Sandra; Polcher, Alexandra; Spottke, Annika; Frölich, Lutz; Hüll, Michael; Jessen, Frank; Kornhuber, Johannes; Maier, Wolfgang; Peters, Oliver; Ramirez, Alfredo; Wiltfang, Jens; Liepelt‐Scarfone, Inga; Becker, Sara; Berg, Daniela; Schulz, Jörg B.; Reetz, Kathrin; Wojtala, Jennifer; Kassubek, Jan; Storch, Alexander; Balzer‐Geldsetzer, Monika; Hilker‐Roggendorf, Rüdiger; Witt, Karsten; [...]

Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments

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  • Medientyp: E-Artikel
  • Titel: Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments
  • Beteiligte: Ophey, Anja; Wolfsgruber, Steffen; Roeske, Sandra; Polcher, Alexandra; Spottke, Annika; Frölich, Lutz; Hüll, Michael; Jessen, Frank; Kornhuber, Johannes; Maier, Wolfgang; Peters, Oliver; Ramirez, Alfredo; Wiltfang, Jens; Liepelt‐Scarfone, Inga; Becker, Sara; Berg, Daniela; Schulz, Jörg B.; Reetz, Kathrin; Wojtala, Jennifer; Kassubek, Jan; Storch, Alexander; Balzer‐Geldsetzer, Monika; Hilker‐Roggendorf, Rüdiger; Witt, Karsten; [...]
  • Erschienen: Wiley, 2021
  • Erschienen in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  • Sprache: Englisch
  • DOI: 10.1002/dad2.12223
  • ISSN: 2352-8729
  • Schlagwörter: Psychiatry and Mental health ; Neurology (clinical)
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Patients with AD‐MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD‐MCI showed lower standardized scores in a set‐shifting measure as an executive task. A cross‐validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD‐MCI versus PD‐MCI.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>The applied test battery successfully discriminated between AD‐MCI and PD‐MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang