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Lourenço, Andre P.; Leite‐Moreira, Adelino F.; Balligand, Jean‐Luc; Bauersachs, Johann; Dawson, Dana; de Boer, Rudolf A.; de Windt, Leon J.; Falcão‐Pires, Inês; Fontes‐Carvalho, Ricardo; Franz, Stefan; Giacca, Mauro; Hilfiker‐Kleiner, Denise; Hirsch, Emilio; Maack, Christoph; Mayr, Manuel; Pieske, Burkert; Thum, Thomas; Tocchetti, Carlo G.; Brutsaert, Dirk L.; Heymans, Stephane

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

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  • Medientyp: E-Artikel
  • Titel: An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
  • Beteiligte: Lourenço, Andre P.; Leite‐Moreira, Adelino F.; Balligand, Jean‐Luc; Bauersachs, Johann; Dawson, Dana; de Boer, Rudolf A.; de Windt, Leon J.; Falcão‐Pires, Inês; Fontes‐Carvalho, Ricardo; Franz, Stefan; Giacca, Mauro; Hilfiker‐Kleiner, Denise; Hirsch, Emilio; Maack, Christoph; Mayr, Manuel; Pieske, Burkert; Thum, Thomas; Tocchetti, Carlo G.; Brutsaert, Dirk L.; Heymans, Stephane
  • Erschienen: Wiley, 2018
  • Erschienen in: European Journal of Heart Failure
  • Sprache: Englisch
  • DOI: 10.1002/ejhf.1059
  • ISSN: 1388-9842; 1879-0844
  • Schlagwörter: Cardiology and Cardiovascular Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long‐term clinical manifestations. We will revise recent advances in animal model development, experimental set‐ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the <jats:italic>in vivo</jats:italic> setting to <jats:italic>in vitro</jats:italic> cell function testing. Additionally, we address new research challenges that require integration of higher‐order inter‐organ and inter‐cell communication to achieve a full systems biology perspective of HFpEF.</jats:p>
  • Zugangsstatus: Freier Zugang