Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka (Oryzias latipes)

Medientyp: E-Artikel
Titel: Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka (Oryzias latipes)
Beteiligte: Grillitsch, Britta; Altmann, Dominik; Schabuss, Michael; Zornig, Horst; Sommerfeld‐Stur, Irene; Möstl, Erich
Erschienen: Wiley, 2010
Erschienen in: Environmental Toxicology and Chemistry
Sprache: Englisch
DOI: 10.1002/etc.176
ISSN: 1552-8618; 0730-7268
Schlagwörter: Health, Toxicology and Mutagenesis ; Environmental Chemistry
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>Glucocorticoid metabolites enter the aquatic environment via mammalian excrements. Molecular structures of their C<jats:sub>19</jats:sub>O<jats:sub>3</jats:sub> metabolites strongly resemble the major fish androgen 11‐ketotestosterone. Therefore, we tested the hypothesis that the cortisol metabolite 5α‐androstan‐3,11,17‐trione acts similarly to 11‐ketotestosterone by employing a fish screening assay for endocrine‐active substances. After 21 d, both 11‐oxygenated compounds had masculinized sex characteristics of the anal fin in female medaka in a dose‐dependent manner. Environ. Toxicol. Chem. 2010;29:1613–1620. © 2010 SETAC</jats:p>

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