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Goyen, Mathias; Herborn, Christoph U.; Vogt, Florian M.; Kröger, Knut; Verhagen, Rüdiger; Yang, Fan; Bosk, Silke; Debatin, Jörg F.; Ruehm, Stefan G.

Using a 1 M Gd‐chelate (gadobutrol) for total‐body three‐dimensional MR angiography: Preliminary experience

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  • Medientyp: E-Artikel
  • Titel: Using a 1 M Gd‐chelate (gadobutrol) for total‐body three‐dimensional MR angiography: Preliminary experience
  • Beteiligte: Goyen, Mathias; Herborn, Christoph U.; Vogt, Florian M.; Kröger, Knut; Verhagen, Rüdiger; Yang, Fan; Bosk, Silke; Debatin, Jörg F.; Ruehm, Stefan G.
  • Erschienen: Wiley, 2003
  • Erschienen in: Journal of Magnetic Resonance Imaging
  • Sprache: Englisch
  • DOI: 10.1002/jmri.10302
  • ISSN: 1053-1807; 1522-2586
  • Schlagwörter: Radiology, Nuclear Medicine and imaging
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>To determine whether higher concentrated gadolinium chelates are advantageous for the recently introduced concept of total‐body magnetic resonance angiography (MRA), allowing whole‐body coverage, extending from the carotid arteries to the runoff vessels, in merely 72 seconds.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>Total‐body three‐dimensional (3D) MRA using a 1 M Gd‐chelate (gadobutrol, Gadovist®, Schering, Berlin, Germany) at a dosage of 0.2 mmol/kg body‐weight (biphasic injection protocol: 1.3 mL/second and 0.7 mL/second) was performed on three healthy volunteers and ten consecutive patients with DSA‐documented peripheral vascular disease. Separated by at least 72 hours, the three healthy volunteers also underwent the same MRA‐protocol, using gadopentetate dimeglumine in equimolar dosages.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Compared to equimolar dosages, mean signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) values in the three volunteers were significantly higher (up to 32.5% for the arteries of the thighs and calves) using gadobutrol. In the ten patients, gadobutrol‐based total‐body MRA accurately assessed significant stenoses (luminal narrowing &gt; 50%) with sensitivities and specificities of 96.2% (95% CI 0.83–0.97) and 95.7% (95% CI 0.84–0.96), respectively, compared to digital subtraction angiography.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The MRA image quality for total‐body MRA provided by the administration of gadobutrol is superior to that obtained following administration of an identical dose of gadopentetate dimeglumine, and therefore shows promise for use as a comprehensive single exam assessing the entire arterial system for the presence of atherosclerotic disease manifestations. J. Magn. Reson. Imaging 2003;17:565–571. © 2003 Wiley‐Liss, Inc.</jats:p></jats:sec>