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Medientyp: E-Artikel Titel: Human cytomegalovirus terminase as a target for antiviral chemotherapy Beteiligte: Bogner, Elke Erschienen: Wiley, 2002 Erschienen in: Reviews in Medical Virology Sprache: Englisch DOI: 10.1002/rmv.344 ISSN: 1052-9276; 1099-1654 Schlagwörter: Infectious Diseases ; Virology Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Herpesviral DNA packaging is a complex process involving binding and cleavage of DNA containing the specific DNA‐packaging motifs, <jats:italic>pac1</jats:italic> and <jats:italic>pac2</jats:italic>, and packaging of the resulting unit‒length genomes into preformed procapsids. This process is believed to be mediated by two packaging proteins, the terminase subunits. In the case of human cytomegalovirus the terminase consists of the proteins pUL56 and pUL89. While pUL56 (i) mediates the specific binding to <jats:italic>pac</jats:italic> sequences on the concatamers, (ii) provides energy for the translocation of the DNA to the procapsids and (iii) associates itself with the capsid for enabling the entry of the DNA into the procapsid, pUL89 is mainly required to effect DNA cleavage. Based on the limited efficacy of the current drugs ganciclovir, cidofovir and foscarnet, new antiviral therapeutics appear to be in demand. Inhibitors targeting pUL56 and/or pUL89 may offer an attractive alternative since mammalian cell DNA replication does not involve cleavage of concatameric DNA. Drugs targeted to terminase‐like proteins should therefore be safe and highly selective. Copyright © 2002 John Wiley & Sons, Ltd.</jats:p>