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Peloso, Gina M.;
van der Lee, Sven J.;
Sims, R.;
van der Lee, S.J.;
Naj, A.C.;
Bellenguez, C.;
Badarinarayan, N.;
Jakobsdottir, J.;
Kunkle, B.W.;
Boland, A.;
Raybould, R.;
Bis, J.C.;
Martin, E.R.;
Grenier‐Boley, B.;
Heilmann‐Heimbach, S.;
Chouraki, V.;
Kuzma, A.B.;
Sleegers, K.;
Vronskaya, M.;
Ruiz, A.;
Graham, R.R.;
Olaso, R.;
Hoffmann, P.;
Grove, M.L.;
[...]
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
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- Medientyp: E-Artikel
- Titel: Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
- Beteiligte: Peloso, Gina M.; van der Lee, Sven J.; Sims, R.; van der Lee, S.J.; Naj, A.C.; Bellenguez, C.; Badarinarayan, N.; Jakobsdottir, J.; Kunkle, B.W.; Boland, A.; Raybould, R.; Bis, J.C.; Martin, E.R.; Grenier‐Boley, B.; Heilmann‐Heimbach, S.; Chouraki, V.; Kuzma, A.B.; Sleegers, K.; Vronskaya, M.; Ruiz, A.; Graham, R.R.; Olaso, R.; Hoffmann, P.; Grove, M.L.; [...]
- Erschienen: Wiley, 2018
- Erschienen in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
- Sprache: Englisch
- DOI: 10.1016/j.dadm.2018.08.008
- ISSN: 2352-8729
- Schlagwörter: Psychiatry and Mental health ; Neurology (clinical)
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (<jats:italic>CETP</jats:italic>) locus is associated with altered HDL‐C. We aimed to assess AD risk by genetically predicted HDL‐C.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Ten single nucleotide polymorphisms within the <jats:italic>CETP</jats:italic> locus predicting HDL‐C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR‐Egger.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Based on 10 single nucleotide polymorphisms distinctly predicting HDL‐C in the <jats:italic>CETP</jats:italic> locus, we found that HDL‐C was not associated with risk of AD (<jats:italic>P</jats:italic> > .7).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Our study does not support the role of HDL‐C on risk of AD through HDL‐C altered by <jats:italic>CETP</jats:italic>. This study does not rule out other mechanisms by which HDL‐C affects risk of AD.</jats:p></jats:sec>
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