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Karp, Natasha A.;
Mason, Jeremy;
Beaudet, Arthur L.;
Benjamini, Yoav;
Bower, Lynette;
Braun, Robert E.;
Brown, Steve D.M.;
Chesler, Elissa J.;
Dickinson, Mary E.;
Flenniken, Ann M.;
Fuchs, Helmut;
Angelis, Martin Hrabe de;
Gao, Xiang;
Guo, Shiying;
Greenaway, Simon;
Heller, Ruth;
Herault, Yann;
Justice, Monica J.;
Kurbatova, Natalja;
Lelliott, Christopher J.;
Lloyd, K.C. Kent;
Mallon, Ann-Marie;
Mank, Judith E.;
Masuya, Hiroshi;
[...]
Prevalence of sexual dimorphism in mammalian phenotypic traits
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- Medientyp: E-Artikel
- Titel: Prevalence of sexual dimorphism in mammalian phenotypic traits
- Beteiligte: Karp, Natasha A.; Mason, Jeremy; Beaudet, Arthur L.; Benjamini, Yoav; Bower, Lynette; Braun, Robert E.; Brown, Steve D.M.; Chesler, Elissa J.; Dickinson, Mary E.; Flenniken, Ann M.; Fuchs, Helmut; Angelis, Martin Hrabe de; Gao, Xiang; Guo, Shiying; Greenaway, Simon; Heller, Ruth; Herault, Yann; Justice, Monica J.; Kurbatova, Natalja; Lelliott, Christopher J.; Lloyd, K.C. Kent; Mallon, Ann-Marie; Mank, Judith E.; Masuya, Hiroshi; [...]
- Erschienen: Springer Science and Business Media LLC, 2017
- Erschienen in: Nature Communications
- Sprache: Englisch
- DOI: 10.1038/ncomms15475
- ISSN: 2041-1723
- Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Abstract</jats:title><jats:p>The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.</jats:p>
- Zugangsstatus: Freier Zugang