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Zillikens, M. Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M.; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory; Broer, Linda; Johnson, Toby; Koller, Daniel L.; Kutalik, Zoltán; Luan, Jian’an; Malkin, Ida; Ried, Janina S.; Smith, Albert V.; Thorleifsson, Gudmar; Vandenput, Liesbeth; Hua Zhao, Jing; Zhang, Weihua; Aghdassi, Ali; Åkesson, Kristina; Amin, Najaf; Baier, Leslie J.; Barroso, Inês; [...]

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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  • Medientyp: E-Artikel
  • Titel: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
  • Beteiligte: Zillikens, M. Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M.; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory; Broer, Linda; Johnson, Toby; Koller, Daniel L.; Kutalik, Zoltán; Luan, Jian’an; Malkin, Ida; Ried, Janina S.; Smith, Albert V.; Thorleifsson, Gudmar; Vandenput, Liesbeth; Hua Zhao, Jing; Zhang, Weihua; Aghdassi, Ali; Åkesson, Kristina; Amin, Najaf; Baier, Leslie J.; Barroso, Inês; [...]
  • Erschienen: Springer Science and Business Media LLC, 2017
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-017-00031-7
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> &lt; 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p>
  • Zugangsstatus: Freier Zugang