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Hansen, Lea B. S.; Roager, Henrik M.; Søndertoft, Nadja B.; Gøbel, Rikke J.; Kristensen, Mette; Vallès-Colomer, Mireia; Vieira-Silva, Sara; Ibrügger, Sabine; Lind, Mads V.; Mærkedahl, Rasmus B.; Bahl, Martin I.; Madsen, Mia L.; Havelund, Jesper; Falony, Gwen; Tetens, Inge; Nielsen, Trine; Allin, Kristine H.; Frandsen, Henrik L.; Hartmann, Bolette; Holst, Jens Juul; Sparholt, Morten H.; Holck, Jesper; Blennow, Andreas; Moll, Janne Marie; [...]

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

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  • Medientyp: E-Artikel
  • Titel: A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
  • Beteiligte: Hansen, Lea B. S.; Roager, Henrik M.; Søndertoft, Nadja B.; Gøbel, Rikke J.; Kristensen, Mette; Vallès-Colomer, Mireia; Vieira-Silva, Sara; Ibrügger, Sabine; Lind, Mads V.; Mærkedahl, Rasmus B.; Bahl, Martin I.; Madsen, Mia L.; Havelund, Jesper; Falony, Gwen; Tetens, Inge; Nielsen, Trine; Allin, Kristine H.; Frandsen, Henrik L.; Hartmann, Bolette; Holst, Jens Juul; Sparholt, Morten H.; Holck, Jesper; Blennow, Andreas; Moll, Janne Marie; [...]
  • Erschienen: Springer Science and Business Media LLC, 2018
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-018-07019-x
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.</jats:p>
  • Zugangsstatus: Freier Zugang