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Kundu, Rhia; Narean, Janakan Sam; Wang, Lulu; Fenn, Joseph; Pillay, Timesh; Fernandez, Nieves Derqui; Conibear, Emily; Koycheva, Aleksandra; Davies, Megan; Tolosa-Wright, Mica; Hakki, Seran; Varro, Robert; McDermott, Eimear; Hammett, Sarah; Cutajar, Jessica; Thwaites, Ryan S.; Parker, Eleanor; Rosadas, Carolina; McClure, Myra; Tedder, Richard; Taylor, Graham P.; Dunning, Jake; Lalvani, Ajit

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

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  • Medientyp: E-Artikel
  • Titel: Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts
  • Beteiligte: Kundu, Rhia; Narean, Janakan Sam; Wang, Lulu; Fenn, Joseph; Pillay, Timesh; Fernandez, Nieves Derqui; Conibear, Emily; Koycheva, Aleksandra; Davies, Megan; Tolosa-Wright, Mica; Hakki, Seran; Varro, Robert; McDermott, Eimear; Hammett, Sarah; Cutajar, Jessica; Thwaites, Ryan S.; Parker, Eleanor; Rosadas, Carolina; McClure, Myra; Tedder, Richard; Taylor, Graham P.; Dunning, Jake; Lalvani, Ajit
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-27674-x
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.</jats:p>
  • Zugangsstatus: Freier Zugang