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Goërtz, Yvonne M. J.; Braamse, Annemarie M. J.; Spruit, Martijn A.; Janssen, Daisy J. A.; Ebadi, Zjala; Van Herck, Maarten; Burtin, Chris; Peters, Jeannette B.; Sprangers, Mirjam A. G.; Lamers, Femke; Twisk, Jos W. R.; Thong, Melissa S. Y.; Vercoulen, Jan H.; Geerlings, Suzanne E.; Vaes, Anouk W.; Beijers, Rosanne J. H. C. G.; van Beers, Martijn; Schols, Annemie M. W. J.; Rosmalen, Judith G. M.; Knoop, Hans

Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study

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  • Medientyp: E-Artikel
  • Titel: Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study
  • Beteiligte: Goërtz, Yvonne M. J.; Braamse, Annemarie M. J.; Spruit, Martijn A.; Janssen, Daisy J. A.; Ebadi, Zjala; Van Herck, Maarten; Burtin, Chris; Peters, Jeannette B.; Sprangers, Mirjam A. G.; Lamers, Femke; Twisk, Jos W. R.; Thong, Melissa S. Y.; Vercoulen, Jan H.; Geerlings, Suzanne E.; Vaes, Anouk W.; Beijers, Rosanne J. H. C. G.; van Beers, Martijn; Schols, Annemie M. W. J.; Rosmalen, Judith G. M.; Knoop, Hans
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-00337-z
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generic. The Dutch Lifelines cohort was used, including 78,363 subjects with (n = 31,039, 53 ± 12 years, 33% male) and without (n = 47,324, 48 ± 12 years, 46% male) ≥ 1 of 23 chronic diseases. Fatigue was assessed with the Checklist Individual Strength-Fatigue. Compared to participants without a chronic disease, a higher proportion of participants with ≥ 1 chronic disease were severely (23% versus 15%, <jats:italic>p</jats:italic> &lt; 0.001) and chronically (17% versus 10%, <jats:italic>p</jats:italic> &lt; 0.001) fatigued. The odds of having severe fatigue (OR [95% CI]) increased from 1.6 [1.5–1.7] with one chronic disease to 5.5 [4.5–6.7] with four chronic diseases; for chronic fatigue from 1.5 [1.5–1.6] to 4.9 [3.9–6.1]. Multiple trans-diagnostic predisposing and associated factors of fatigue were found, explaining 26% of variance in fatigue in chronic disease. Severe and chronic fatigue are highly prevalent in chronic diseases. Multi-morbidity increases the odds of having severe and chronic fatigue. Several trans-diagnostic factors were associated with fatigue, providing a rationale for a trans-diagnostic approach.</jats:p>
  • Zugangsstatus: Freier Zugang