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Masuda, Hiroki;
Mori, Masahiro;
Hirano, Shigeki;
Uzawa, Akiyuki;
Uchida, Tomohiko;
Muto, Mayumi;
Ohtani, Ryohei;
Aoki, Reiji;
Hirano, Yoshiyuki;
Iwatsubo, Takeshi;
Asada, Takashi;
Arai, Hiroyuki;
Sugishita, Morihiro;
Matsuda, Hiroshi;
Ito, Kengo;
Senda, Michio;
Ishii, Kenji;
Kuwano, Ryozo;
Ikeuchi, Takeshi;
Sato, Noriko;
Sato, Hajime;
Shimohama, Shun;
Saitoh, Masaki;
Yamauchi, Rika;
[...]
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
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- Medientyp: E-Artikel
- Titel: Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
- Beteiligte: Masuda, Hiroki; Mori, Masahiro; Hirano, Shigeki; Uzawa, Akiyuki; Uchida, Tomohiko; Muto, Mayumi; Ohtani, Ryohei; Aoki, Reiji; Hirano, Yoshiyuki; Iwatsubo, Takeshi; Asada, Takashi; Arai, Hiroyuki; Sugishita, Morihiro; Matsuda, Hiroshi; Ito, Kengo; Senda, Michio; Ishii, Kenji; Kuwano, Ryozo; Ikeuchi, Takeshi; Sato, Noriko; Sato, Hajime; Shimohama, Shun; Saitoh, Masaki; Yamauchi, Rika; [...]
- Erschienen: Springer Science and Business Media LLC, 2023
- Erschienen in: Scientific Reports
- Sprache: Englisch
- DOI: 10.1038/s41598-023-38893-1
- ISSN: 2045-2322
- Schlagwörter: Multidisciplinary
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Abstract</jats:title><jats:p>We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, <jats:italic>P</jats:italic> = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, <jats:italic>P</jats:italic> = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.41, <jats:italic>P</jats:italic> = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.43, <jats:italic>P</jats:italic> = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD. </jats:p>
- Zugangsstatus: Freier Zugang