Erschienen:
Royal Society of Chemistry (RSC), 2015
Erschienen in:Organic & Biomolecular Chemistry
Sprache:
Englisch
DOI:
10.1039/c4ob02301c
ISSN:
1477-0520;
1477-0539
Entstehung:
Anmerkungen:
Beschreibung:
<p>Boosting the alkylation power of chalcones creates new anti-inflammatory agents. Thus NF-κB-dependent proteins are inhibited and Nrf2-dependent ones activated. The activity enhancement relies solely and very effectively on the α-substituent of the α,β-unsaturated carbonyl unit.</p>