• Medientyp: E-Artikel
  • Titel: Detection of Gender Differences in Incomplete Revascularization after Coronary Artery Bypass Surgery Varies with Classification Technique
  • Beteiligte: Oertelt-Prigione, Sabine; Kendel, Friederike; Kaltenbach, Martin; Hetzer, Roland; Regitz-Zagrosek, Vera; Baretti, Rufus
  • Erschienen: Hindawi Limited, 2013
  • Erschienen in: BioMed Research International
  • Sprache: Englisch
  • DOI: 10.1155/2013/108475
  • ISSN: 2314-6133; 2314-6141
  • Schlagwörter: General Immunology and Microbiology ; General Biochemistry, Genetics and Molecular Biology ; General Medicine
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  • Beschreibung: <jats:p><jats:italic>Background</jats:italic>. Incomplete revascularization negatively affects survival after coronary artery bypass surgery (CABG). Since gender and classification technique might impact outcome and reporting, we investigated their effect on revascularization patterns and mortality.<jats:italic>Methods</jats:italic>. A cohort of bypass patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mo>1545</mml:mo></mml:math>, 23% women) was enrolled prospectively. The degree of revascularization was determined as mathematical difference between affected vessels upon diagnosis and number of grafts or the surgeon’s rating on the case file.<jats:italic>Results</jats:italic>. Although men displayed more triple-vessel disease, they obtained complete revascularization more frequently than women (85% versus 77%,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mo>0.</mml:mo><mml:mn fontstyle="italic">001</mml:mn></mml:math>). The two calculation methods identified analogous percentages of incompletely revascularized patients, yet there was only a 50% overlap between the two groups. Mathematically, more women, older patients, and patients with NYHA class III/IV appeared incompletely revascularized, while the surgeons identified more patients undergoing technically challenging procedures. Regardless of the definition, incompleteness was a significant risk factor for mortality in both genders (mathematical calculation: HR 2.62, 95% CI 1.76–3.89,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0</mml:mn><mml:mo>.</mml:mo><mml:mn fontstyle="italic">001</mml:mn></mml:math>; surgeon: HR 2.04, 95% CI 1.35–3.89,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0</mml:mn><mml:mo>.</mml:mo><mml:mn fontstyle="italic">001</mml:mn></mml:math>).<jats:italic>Conclusions</jats:italic>. Given the differences in identification patterns, we advise that the mathematical calculation be performed after-procedure in all patients regardless of the surgeons’ rating to uncover additional subjects at increased risk.</jats:p>
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