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Medientyp:
E-Artikel
Titel:
Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver
Beteiligte:
Abdel-Wahab, Ali F.;
Al-Harizy, Wahid M.
Erschienen:
Hindawi Limited, 2013
Erschienen in:ISRN Anesthesiology
Sprache:
Englisch
DOI:
10.1155/2013/517478
ISSN:
2090-5556
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Propofol is an intravenous anesthetic, reported to have a protective effect against ischemia/reperfusion (I/R) injury in heart and brain, but no definite data are available concerning its effect in hepatic I/R. This work investigated the effect of propofol anesthesia on hepatic I/R injury using <jats:italic>in vivo</jats:italic> rat model. Four groups of rats were included: sham operated, I/R (30 min ischemia and 2 h reperfusion), I/R treated with propofol (10 mg/kg/h), and I/R treated with propofol (20 mg/kg/h). Liver enzyme leakage, TNF-<jats:italic>α</jats:italic> and caspase-3 levels, and antiapoptotic Bcl-xL/apoptotic Bax gene expression, together with histopathological changes, were used to evaluate the extent of hepatic I/R injury. Compared with sham-operated group, I/R group showed significant increase in serum levels of liver enzymes (ALT, AST), TNF-<jats:italic>α</jats:italic>, and caspase-3 and significant decrease in the Bcl-xL/Bax ratio, associated with histopathologic damage in liver. Propofol infusion significantly attenuated these changes with reduced hepatic histopathologic lesions compared with nonpreconditioned I/R group. However, no significant differences were found between two groups treated with different doses of propofol. In conclusion, propofol infusion reduced hepatic I/R injury with decreased markers of cellular apoptosis. Therefore, propofol anesthesia may provide a useful hepatic protection during liver surgery.</jats:p>