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<jats:title>Abstract</jats:title>
<jats:p>Background: A positive relationship between periodontal disease and pancreatic cancer risk has been observed in previous epidemiological studies. In a cohort study of health professional men, never smokers reporting a positive history of periodontal disease had a 2-fold higher risk of pancreatic cancer compared with those reporting no periodontal disease (RR = 2.09, 95% CI = 1.18-3.71). These findings suggest that oral bacteria may be able to disseminate to the pancreas or may be associated with risk indirectly. We examined the relationship between the presence of antibodies to 25 diverse strains of oral bacteria and pancreatic cancer risk in a prospective study. Methods: Antibodies to oral bacteria were measured in prediagnostic blood samples of 405 pancreatic cancer cases and 416 matched controls nested within the European Prospective Investigation on Cancer (EPIC), a large cohort study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results: Individuals with high antibody levels to Porphyromonas gingivalis ATTC 53978 (&gt;200 ng/ml), a pathogenic periodontal bacteria, had a two-fold higher risk of pancreatic cancer (OR = 2.14, 95% CI =1.05-4.36) compared with individuals with low levels of antibody (&lt;200ng/ml). To explore the association with common oral bacteria, we performed a cluster analysis and obtained two clusters that aggregated individuals according to their antibody profiles. A substantially lower risk of pancreatic cancer was observed in the cluster with consistently elevated levels of antibodies, compared to a second cluster with overall lower levels (OR = 0.55, 95% CI = 0.36-0.83). Conclusions: In this study using prediagnostic bloods, we find support for a positive association between periodontal disease and pancreatic cancer. Additionally, our results further suggest that certain oral bacteria or an enhanced immune surveillance may provide some protection against pancreatic cancer. Our findings are consistent with dental research on periodontal disease etiology and treatment. Whether periodontal disease is causally related to pancreatic cancer or simply a marker of underlying immune response needs to be further elucidated.</jats:p>
<jats:p>Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-328. doi:1538-7445.AM2012-LB-328</jats:p>