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Jeger, Raban V.; Schneiter, Stefan; Kaiser, Christoph; Bonetti, Piero O.; Brunner-La Rocca, Hanspeter; Handke, Michael; Osswald, Stefan; Buser, Peter T.; Pfisterer, Matthias E.

Drug-Eluting Stents Compared with Bare Metal Stents Improve Late Outcome after Saphenous Vein Graft but Not after Large Native Vessel Interventions

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  • Medientyp: E-Artikel
  • Titel: Drug-Eluting Stents Compared with Bare Metal Stents Improve Late Outcome after Saphenous Vein Graft but Not after Large Native Vessel Interventions
  • Beteiligte: Jeger, Raban V.; Schneiter, Stefan; Kaiser, Christoph; Bonetti, Piero O.; Brunner-La Rocca, Hanspeter; Handke, Michael; Osswald, Stefan; Buser, Peter T.; Pfisterer, Matthias E.
  • Erschienen: S. Karger AG, 2009
  • Erschienen in: Cardiology
  • Sprache: Englisch
  • DOI: 10.1159/000137699
  • ISSN: 0008-6312; 1421-9751
  • Schlagwörter: Pharmacology (medical) ; Cardiology and Cardiovascular Medicine
  • Entstehung:
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  • Beschreibung: <jats:p>&lt;i&gt;Objectives:&lt;/i&gt; To define long-term efficacy of different stent types in saphenous vein graft (SVG) interventions. &lt;i&gt;Methods:&lt;/i&gt; In BASKET (Basel Stent Cost Effectiveness Trial), major adverse cardiac events (MACE), i.e. cardiac death, myocardial infarction and symptom-driven target vessel revascularization (TVR) were assessed after 18 months comparing drug-eluting stents (DES) versus bare metal stents (BMS), and SVG and large native vessels (≧3.0 mm). &lt;i&gt;Results:&lt;/i&gt; Large vessel interventions were performed in 605 patients. Patients with SVG interventions (n = 47, 8%) were older and had more often hypertension, prior myocardial infarction, prior revascularization and multivessel disease and less frequent ST-elevation myocardial infarction than patients with large native vessel interventions (n = 558, 92%). Stent number and length were higher in SVG than in large native vessel interventions. Baseline characteristics were similar for DES and BMS. In SVG stenting, long-term outcome was better in DES- than in BMS-treated patients (MACE 21 vs. 62%, p = 0.007, mainly due to TVR 18 vs. 46%, p = 0.045), but for large native vessel stenting, no significant difference was noted (MACE: 13 vs. 16%, p = 0.40). &lt;i&gt;Conclusions:&lt;/i&gt; Among patients with SVG disease, treatment with DES resulted in a better long-term outcome than treatment with BMS. In contrast, no DES benefit was found in similarly sized native vessels regarding MACE.</jats:p>