The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study

Medientyp: E-Artikel
Titel: The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study
Beteiligte: Omrani, Ali S.; Almaslamani, Muna A.; Daghfal, Joanne; Alattar, Rand A.; Elgara, Mohamed; Shaar, Shahd H.; Ibrahim, Tawheeda B. H.; Zaqout, Ahmed; Bakdach, Dana; Akkari, Abdelrauof M.; Baiou, Anas; Alhariri, Bassem; Elajez, Reem; Husain, Ahmed A. M.; Badawi, Mohamed N.; Abid, Fatma Ben; Abu Jarir, Sulieman H.; Abdalla, Shiema; Kaleeckal, Anvar; Choda, Kris; Chinta, Venkateswara R.; Sherbash, Mohamed A.; Al-Ismail, Khalil; Abukhattab, Mohammed; [...]
Erschienen: Springer Science and Business Media LLC, 2020
Erschienen in: BMC Infectious Diseases
Sprache: Englisch
DOI: 10.1186/s12879-020-05511-8
ISSN: 1471-2334
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Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>There are limited data on Coronavirus Disease 2019 (COVID-19) outcomes at a national level, and none after 60 days of follow up. The aim of this study was to describe national, 60-day all-cause mortality associated with COVID-19, and to identify risk factors associated with admission to an intensive care unit (ICU).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This was a retrospective cohort study including the first consecutive 5000 patients with COVID-19 in Qatar who completed 60 days of follow up by June 17, 2020. The primary outcome was all-cause mortality at 60 days after COVID-19 diagnosis. In addition, we explored risk factors for admission to ICU.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Included patients were diagnosed with COVID-19 between February 28 and April 17, 2020. The majority (4436, 88.7%) were males and the median age was 35 years [interquartile range (IQR) 28–43]. By 60 days after COVID-19 diagnosis, 14 patients (0.28%) had died, 10 (0.2%) were still in hospital, and two (0.04%) were still in ICU. Fatal COVID-19 cases had a median age of 59.5 years (IQR 55.8–68), and were mostly males (13, 92.9%). All included pregnant women (26, 0.5%), children (131, 2.6%), and healthcare workers (135, 2.7%) were alive and not hospitalized at the end of follow up.</jats:p> <jats:p>A total of 1424 patients (28.5%) required hospitalization, out of which 108 (7.6%) were admitted to ICU. Most frequent co-morbidities in hospitalized adults were diabetes (23.2%), and hypertension (20.7%). Multivariable logistic regression showed that older age [adjusted odds ratio (aOR) 1.041, 95% confidence interval (CI) 1.022–1.061 per year increase; <jats:italic>P</jats:italic> < 0.001], male sex (aOR 4.375, 95% CI 1.964–9.744; <jats:italic>P</jats:italic> < 0.001), diabetes (aOR 1.698, 95% CI 1.050–2.746; P 0.031), chronic kidney disease (aOR 3.590, 95% CI 1.596–8.079, P 0.002), and higher BMI (aOR 1.067, 95% CI 1.027–1.108 per unit increase; P 0.001), were all independently associated with increased risk of ICU admission.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In a relatively younger national cohort with a low co-morbidity burden, COVID-19 was associated with low all-cause mortality. Independent risk factors for ICU admission included older age, male sex, higher BMI, and co-existing diabetes or chronic kidney disease.</jats:p> </jats:sec>
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