Beschreibung:
<jats:title>Abstract</jats:title><jats:p>The short‐term kinetics of infectious HIV titers, HIV copy numbers and p24‐antigen during the first 28 days of AZT monotherapy were evaluated. In three of four patients, infectious HIV was culturable and infectious titers rose 2‐ and 4‐fold compared to baseline values. This increase was neither associated with mutations conferring resistance to AZT nor a switch from NSI to SI phenotypes. Two patients showed an increase of plasma infectivity associated with a reduction of HIV copies and p24‐antigen. We conclude that transient dissociations of plasma infectivity and HIV copy numbers occur during early AZT monotherapy.</jats:p>