> Detailanzeige

Korshunov, Andrey; Jakobiec, Frederick A.; Eberhart, Charles G.; Hovestadt, Volker; Capper, David; Jones, David T.W.; Sturm, Dominik; Stagner, Anna M.; Edward, Deepak P.; Eagle, Ralph C.; Proia, Alan D.; Koch, Arend; Ryzhova, Marina; Ektova, Anastasia; Schüller, Ulrich; Zheludkova, Olga; Lichter, Peter; von Deimling, Andreas; Pfister, Stefan M.; Kool, Marcel

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities
  • Beteiligte: Korshunov, Andrey; Jakobiec, Frederick A.; Eberhart, Charles G.; Hovestadt, Volker; Capper, David; Jones, David T.W.; Sturm, Dominik; Stagner, Anna M.; Edward, Deepak P.; Eagle, Ralph C.; Proia, Alan D.; Koch, Arend; Ryzhova, Marina; Ektova, Anastasia; Schüller, Ulrich; Zheludkova, Olga; Lichter, Peter; von Deimling, Andreas; Pfister, Stefan M.; Kool, Marcel
  • Erschienen: Wiley, 2015
  • Erschienen in: Neuropathology
  • Sprache: Englisch
  • DOI: 10.1111/neup.12227
  • ISSN: 0919-6544; 1440-1789
  • Schlagwörter: Neurology (clinical) ; General Medicine ; Pathology and Forensic Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Intraocular medulloepithelioma (IO MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. These ocular neoplasms have been compared with intracranial medulloepitheliomas or other histologic variants of CNS embryonal tumor with multilayered rosettes (CNS ETMR) due to their morphological mimicry. We performed comprehensive molecular analysis to explore the histogenetic and biologic relationships between 22 IO MEPL and 68 CNS ETMR. Routinely prepared paraffin‐embedded samples were assessed for genome‐wide methylation profiles using the Illumina Methylation 450k BeadChip array. We identified strong cytogenetic and epigenetic differences between ocular neoplasms and CNS ETMR. None of the IO MEPL cases displayed the ETMR‐specific amplification of the <jats:italic>C19MC</jats:italic> locus. Instead, cytogenetic analysis of the IO MEPL showed numerous copy number aberrations which involved either whole chromosomes or chromosomal arms; recurrent aberrations in these tumors affected chromosomes 1p, 4, 8 and 16p. DNA methylation patterns were also strikingly different between these two tumor entities, suggesting that they do not share common origins and biological behaviors. Comparative cluster analysis of 198 pediatric CNS tumors and 22 IO MEPL revealed a clear demarcation of the CNS ETMR and IO MEPL profiles from other CNS entities. In conclusion, although IO MEPL shares some histopathological features with CNS ETMR, they manifest striking molecular diversity at the cytogenetic and epigenetic levels. Consequently they deserve a separate nosologic designation in future tumor classifications, where CNS MEPL could be designated as a histological variant of CNS ETMR.</jats:p>