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Zanoni, Paolo;
Khetarpal, Sumeet A.;
Larach, Daniel B.;
Hancock-Cerutti, William F.;
Millar, John S.;
Cuchel, Marina;
DerOhannessian, Stephanie;
Kontush, Anatol;
Surendran, Praveen;
Saleheen, Danish;
Trompet, Stella;
Jukema, J. Wouter;
De Craen, Anton;
Deloukas, Panos;
Sattar, Naveed;
Ford, Ian;
Packard, Chris;
Majumder, Abdullah al Shafi;
Alam, Dewan S.;
Di Angelantonio, Emanuele;
Abecasis, Goncalo;
Chowdhury, Rajiv;
Erdmann, Jeanette;
Nordestgaard, Børge G.;
[...]
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
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- Medientyp: E-Artikel
- Titel: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
- Beteiligte: Zanoni, Paolo; Khetarpal, Sumeet A.; Larach, Daniel B.; Hancock-Cerutti, William F.; Millar, John S.; Cuchel, Marina; DerOhannessian, Stephanie; Kontush, Anatol; Surendran, Praveen; Saleheen, Danish; Trompet, Stella; Jukema, J. Wouter; De Craen, Anton; Deloukas, Panos; Sattar, Naveed; Ford, Ian; Packard, Chris; Majumder, Abdullah al Shafi; Alam, Dewan S.; Di Angelantonio, Emanuele; Abecasis, Goncalo; Chowdhury, Rajiv; Erdmann, Jeanette; Nordestgaard, Børge G.; [...]
- Erschienen: American Association for the Advancement of Science (AAAS), 2016
- Erschienen in: Science
- Sprache: Englisch
- DOI: 10.1126/science.aad3517
- ISSN: 0036-8075; 1095-9203
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>A scavenger that protects the heart</jats:title> <jats:p> Coronary heart disease is a tale of two forms of plasma cholesterol. In contrast to the well-established effects of “bad” cholesterol (LDL-C), the role of “good” cholesterol (HDL-C) is mysterious. Elevated HDL-C correlates with a lower risk of heart disease, yet drugs that raise HDL-C levels do not reduce risk. Zanoni <jats:italic>et al.</jats:italic> found that some people with exceptionally high levels of HDL-C carry a rare sequence variant in the gene encoding the major HDL-C receptor, scavenger receptor BI. This variant destroys the receptor's ability to take up HDL-C. Interestingly, people with this variant have a higher risk of heart disease despite having high levels of HDL-C. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6278" page="1166" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad3517">1166</jats:related-article> </jats:p>