Beschreibung:
<jats:title>ABSTRACT</jats:title><jats:p><jats:italic>Plasmodium</jats:italic>liver stages represent potential targets for antimalarial prophylactic drugs. Nevertheless, there is a lack of molecules active on these stages. We have now developed a new approach for the high-throughput screening of drug activity on<jats:italic>Plasmodium</jats:italic>liver stages in vitro, based on an infrared fluorescence scanning system. This method allowed us to count automatically and rapidly<jats:italic>Plasmodium</jats:italic>-infected hepatocytes, using different hepatic cells and different<jats:italic>Plasmodium</jats:italic>species, including<jats:italic>Plasmodium falciparum</jats:italic>. This new technique is well adapted for high-throughput drug screening and should facilitate the identification of new antimalarial compounds active on<jats:italic>Plasmodium</jats:italic>liver stages.</jats:p>