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Baumann, Ulrich; Schulte, Johannes H.; Groß, Jonathan P.; Beier, Rita; Ludwig, Marius; Wahn, Volker; Hofmann, Jörg; Maecker-Kolhoff, Britta; Sauer, Martin; Kaiser-Labusch, Petra; Karimian, Negin; Blume-Peytavi, Ulrike; Ghoreschi, Franziska; Ott, Hagen; Perelygina, Ludmila; Klemann, Christian; Blankenstein, Oliver; von Bernuth, Horst; Krüger, Renate

Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

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  • Medientyp: E-Artikel
  • Titel: Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation
  • Beteiligte: Baumann, Ulrich; Schulte, Johannes H.; Groß, Jonathan P.; Beier, Rita; Ludwig, Marius; Wahn, Volker; Hofmann, Jörg; Maecker-Kolhoff, Britta; Sauer, Martin; Kaiser-Labusch, Petra; Karimian, Negin; Blume-Peytavi, Ulrike; Ghoreschi, Franziska; Ott, Hagen; Perelygina, Ludmila; Klemann, Christian; Blankenstein, Oliver; von Bernuth, Horst; Krüger, Renate
  • Erschienen: Frontiers Media SA, 2022
  • Erschienen in: Frontiers in Immunology
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fimmu.2022.886540
  • ISSN: 1664-3224
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.</jats:p>
  • Zugangsstatus: Freier Zugang