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Bauswein, Markus; Eidenschink, Lisa; Knoll, Gertrud; Neumann, Bernhard; Angstwurm, Klemens; Zoubaa, Saida; Riemenschneider, Markus J; Lampl, Benedikt M J; Pregler, Matthias; Niller, Hans Helmut; Jantsch, Jonathan; Gessner, André; Eberhardt, Yvonne; Huppertz, Gunnar; Schramm, Torsten; Kühn, Stefanie; Koller, Michael; Drasch, Thomas; Ehrl, Yvonne; Banas, Bernhard; Offner, Robert; Schmidt, Barbara; Banas, Miriam C.

Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany

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  • Medientyp: E-Artikel
  • Titel: Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany
  • Beteiligte: Bauswein, Markus; Eidenschink, Lisa; Knoll, Gertrud; Neumann, Bernhard; Angstwurm, Klemens; Zoubaa, Saida; Riemenschneider, Markus J; Lampl, Benedikt M J; Pregler, Matthias; Niller, Hans Helmut; Jantsch, Jonathan; Gessner, André; Eberhardt, Yvonne; Huppertz, Gunnar; Schramm, Torsten; Kühn, Stefanie; Koller, Michael; Drasch, Thomas; Ehrl, Yvonne; Banas, Bernhard; Offner, Robert; Schmidt, Barbara; Banas, Miriam C.
  • Erschienen: MDPI AG, 2023
  • Erschienen in: Viruses
  • Sprache: Englisch
  • DOI: 10.3390/v15010188
  • ISSN: 1999-4915
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid-organ transplantation”) to assess whether there are undetected oligo- or asymptomatic courses of infection. A total of 216 healthy blood donors and 280 outpatients after solid organ transplantation were screened by a recombinant BoDV-1 ELISA followed by an indirect immunofluorescence assay (iIFA) as confirmatory test. For comparison, 288 serum and 258 cerebrospinal fluid (CSF) samples with a request for tick-borne encephalitis (TBE) diagnostics were analyzed for BoDV-1 infections. ELISA screening reactivity rates ranged from 3.5% to 18.6% depending on the cohort and the used ELISA antigen, but only one sample of a patient from the cohort with requested TBE diagnostics was confirmed to be positive for anti-BoDV-1-IgG by iIFA. In addition, the corresponding CSF sample of this patient with a three-week history of severe neurological disease tested positive for BoDV-1 RNA. Due to the iIFA results, all other results were interpreted as false-reactive in the ELISA screening. By linear serological epitope mapping, cross-reactions with human and bacterial proteins were identified as possible underlying mechanism for the false-reactive ELISA screening results. In conclusion, no oligo- or asymptomatic infections were detected in the studied cohorts. Serological tests based on a single recombinant BoDV-1 antigen should be interpreted with caution, and an iIFA should always be performed in addition.</jats:p>
  • Zugangsstatus: Freier Zugang